Which of the following antibiotics is associated with the risk of tendon rupture?

Fluoroquinolones are a class of antibiotics known for their broad-spectrum activity against both gram-negative and gram-positive bacteria. One of the significant risks associated with fluoroquinolone use is tendon injury, including tendon rupture, particularly of the Achilles tendon. This risk is higher in certain populations, including the elderly, individuals on concurrent corticosteroid therapy, and those with a history of tendon disorders.

The mechanism behind this adverse effect likely involves the impact of fluoroquinolones on collagen synthesis and degradation. Studies have shown that these antibiotics can alter the structural integrity of tendons, leading to an increased likelihood of rupture.

In clinical practice, it is essential to be aware of this potential complication, especially when prescribing fluoroquinolones to at-risk populations. Alternative antibiotics may be considered for these patients to avoid the risk of tendon-related side effects.