Which medication class is recommended for migraine prophylaxis occurring more than three times a month?

For migraine prophylaxis in individuals experiencing migraines more than three times a month, beta-blockers are a well-established and recommended option. This medication class has been shown to effectively decrease the frequency and severity of migraine attacks. Beta-blockers, such as propranolol and metoprolol, are believed to work by modulating adrenergic tone and possibly affecting both blood flow and inflammatory processes linked to migraine pathophysiology.

Other medication classes have differing roles in migraine management. For instance, triptans are primarily used for abortive treatment during a migraine attack, rather than for prevention. Calcium channel blockers may have some efficacy in certain cases, but they are not considered first-line agents for migraine prophylaxis. NSAIDs are also mainly utilized for acute treatment rather than for preventive measures on a regular basis.

In summary, beta-blockers are favored for prophylaxis due to their proven benefits in reducing migraine frequency, their safety profile, and their effectiveness in a significant number of patients with recurrent migraines.