What is the most appropriate treatment for PVCs that are frequent and symptomatic?

When dealing with frequent and symptomatic premature ventricular contractions (PVCs), beta-blockers are a common and effective first-line treatment. The mechanism of action of beta-blockers is to reduce heart rate and myocardial contractility, helping to ameliorate symptoms associated with PVCs. Increasing the dosage of beta-blockers can lead to improved control of PVC frequencies and can reduce symptoms such as palpitations and anxiety caused by these arrhythmias.

Beta-blockers are particularly useful in patients who experience PVCs related to increased adrenergic activity, such as stress or anxiety, and they can also provide benefits in patients with underlying structural heart disease or cardiomyopathy.

While other options may be considered in certain contexts, they are generally not the initial approach for treating symptomatic PVCs. Aspirin is used primarily for its antiplatelet effects and would not address the arrhythmia itself. Digoxin can sometimes be used in heart failure patients with concurrent atrial fibrillation but is not first-line for PVCs. Defibrillation is indicated for life-threatening arrhythmias such as ventricular tachycardia or ventricular fibrillation and is not applicable for isolated PVCs unless they degenerate into a more dangerous rhythm.

Therefore, the most appropriate treatment