What is the first-line treatment for Restless Legs Syndrome?

The first-line treatment for Restless Legs Syndrome (RLS) is pramipexole, a dopamine agonist. This choice is favored because dopamine agonists are effective in alleviating the symptoms of RLS, which include an irresistible urge to move the legs, often accompanied by uncomfortable sensations. Pramipexole works by stimulating dopamine receptors in the brain, which helps improve motor function and reduces the urge to move the legs.

Ropinirole, another dopamine agonist, is also an effective treatment for RLS and could be considered a competitor treatment option. However, pramipexole is often highlighted in clinical guidelines, potentially due to its approved indications and favorable side effect profile in certain populations.

While carbidopa/levodopa could be beneficial for patients who experience RLS secondary to Parkinson's disease, it is not typically used as a first-line treatment for idiopathic RLS because long-term use might lead to augmentation, a worsening of symptoms. Gabapentin and its analogs are used for RLS as well, particularly in cases of neuropathic pain or when patients do not respond to dopamine agonists, but they are not considered first-line therapy.

Overall, pramipexole’s effectiveness and