What is a potential adverse effect of using isoniazid?

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Isoniazid is an antibiotic primarily used to treat tuberculosis. One of the significant adverse effects associated with isoniazid therapy is hepatotoxicity. This toxicity occurs because the drug is metabolized in the liver, and it can lead to an increase in liver enzymes, which may indicate liver damage. Patients on isoniazid require monitoring of liver function tests, especially those with pre-existing liver disease, alcohol use, or those taking other medications that affect the liver.

While skin rash and nausea can occur with isoniazid use, they are typically less severe and less common than hepatotoxicity. Nephrotoxicity is not generally associated with isoniazid. Therefore, hepatotoxicity stands out as a key concern, making it an important aspect to monitor during treatment.

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