What is a common side effect associated with the use of aminoglycosides?

Aminoglycosides, which include antibiotics such as gentamicin and amikacin, are known for their potential nephrotoxic effects. This nephrotoxicity arises primarily because these drugs are eliminated by the kidneys and can accumulate in renal tubular cells, leading to cellular damage. The risk of nephrotoxicity is dose-dependent and increases with prolonged use or in patients with underlying kidney impairment.

Monitoring renal function and adjusting dosages based on kidney function is critical when treating patients with aminoglycosides. Other common side effects of aminoglycosides include ototoxicity, which can result in hearing loss or balance issues, but nephrotoxicity stands out as a well-recognized and significant concern in clinical practice. The management of this risk involves careful monitoring and considering alternative antibiotics when necessary, especially in high-risk populations.